A partial change in use, such as renting out a basement suite while you continue to live upstairs, is treated differently than renting the entire home to a tenant while you live elsewhere, and the Canada Revenue Agency's rules on a full change in use can trigger a deemed disposition in the year the change happens.
The calculation generally uses a formula based on the number of years designated as your principal residence, plus one, over your total years of ownership, applied to the total gain, so even a period of rental use does not necessarily eliminate the exemption entirely.
This is general information, not tax advice, and a tax professional should confirm how your specific rental period applies before you list, especially if the rented portion was also reassessed as part of the 80 percent taxable share the City of Saskatoon applies to your property. Get your hand-reviewed valuation from Joel Dyck.